Ensaios clinicos
Ana*** ***** (XX anos)
Post-doc researcher em 3bs Research Group On Biomaterials, Biodegradables And Biomimetics Of University Of Minho
Institute of Engineering of Porto (ISEP)
Braga
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Experiência
Post-doc researcher
3bs Research Group On Biomaterials, Biodegradables And Biomimetics Of University Of Minho
Job-related/Technical Skills - lab work related to the development of natural-based compounds and the exploitation of their bioactivities as anti-bacterial and anti-UV agents, as well as in the field of Alzheimer’s disease: • Extraction/purification of natural-based compounds/extracts; • Synthesis of dendrimers by divergent methodology; • Supramolecular chemistry; • in vitro cell culture (primary cells and cell lines); • Immunocytochemistry; • Cells proliferation and viability assays (DNA and MTS); • SDS-PAGE and Western-blot; • ELISA assays. • Circular Dichroism; • Fluoresce spectrometer • HPLC analysis • Fluorescence and confocal microscopy; • Fourier transform infrared (FTIR) spectroscopy; • Zetasizer Nano (dynamic light scattering system). Computer skills • Microsoft Office (Basic Skills in Information Technology, by University of Minho); • Graphic Software: ImageJ, GIMP, ChemDraw; • Data analysis: GraphPad Prism, Origin, QTools/Qsoft: Mnova NMR - responsible for the Chemistry Laboratory, and maintenance and training actions of several equipment’s (i.e., Fluorescence spectrometer or Circular Dichroism). - worked in different projects (co)funded by EU, FP7, H2020. - involved in the execution of the Twinning project “Chem2Nature” and in the project “NORTHERN DISCOVERIES CTR” of the H2020 Program of the European Commission and Norte2020 regional programme, respectively.
Formação
Chemical Engineering
Institute of Engineering of Porto (ISEP)
set 2006
-
jul 2011
Chemical Engineer - 09/09/2006–30/07/2009 Educational researcher at biotech lab at Institute of Engineering of Porto, Porto (Portugal) - 01/01/2010–27/07/2010 -- MSc Chemical Engineer at Institute of Engineering of Porto, Porto (Portugal) - 01/09/2009–31/07/2011 Educational researcher (Erasmus+) at KAHO Sint-Lieven - Hogeschool, Gent (Belgium) - 02/01/2011–29/06/2011
Idiomas
Inglês - B2
Informações Adicionais
Organizational/Managerial Skills
• Board member of the Portuguese Young Chemists group (GQJ) from the Portuguese Chemical Society (SPQ), from 2016 to 2018; • Portuguese Delegate member in the 13th Delegates Assembly of the European Young Chemists Network (EYCN) from the Young Chemists of the European Chemical Society (EuChemS) • Member of the Organizing Committee of 5th Portuguese Young Chemists Meeting (5th PYCheM) and 1st European Young Chemists Meeting (1st EYCheM) held in Guimarães, Portugal, from 26th to 29thApril 2016. • Member of the Local Organizing Committee of several International Conferences (Chem2Nature, Forecast and TermStem Conferences). • Founding member of the PhDynamics Group from 3B’s Research Group (2018) • Responsible for the maintenance and good laboratory and safety practices (accordingly to the ISO9001:2015) of a chemistry laboratory. • Responsible for the maintenance and training actions of equipment: Circular Dichroism; Fluorescence spectrometer; Rotary evaporator. • Board member of the aeISEP from 2007-2008;
Academic Outputs
Papers in international scientific journals with referees (as first author) 1. Araújo A. R., Reis, R. L. & Pires, R. A, (2020), From natural compounds to polyphenol-terminated nanosystems in Alzheimer disease (submitted) 2. Araújo A. R., Araújo, C. A., Reis, R. L. & Pires, R. A, (2020), Vescalagin and castalagin present bactericidal activity towards Methicillin-resistant bacteria, ACS Biomaterials Science & Engineering 2021, 10.1021/acsbiomaterials.0c01698. 3. Araújo A. R., Reis, R. L. & Pires, R. A, (2020), Glucosamine analogues as modulators of amyloid-β toxicity, ACS Medicinal Chemistry Letters 2021, 10.1021/acsmedchemlett.0c00350 4. Araújo A. R., Correa J., Dominguez-Arca V., Reis, R. L., Fernandez-Megia E. & Pires, R. A, (2020), Functional gallic acid-based dendrimers as synthetic nanotools to remodel amyloid-beta 42 intononcytotoxicforms (submitted) 5. Araújo A. R., Gigante S. C., Taboada P., Reis R. L., and Pires R. A., "Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure", Chemical Communications (RSC), doi:10.1039/D0CC00192A, 2020. 6. Araújo A. R., Soares da Costa D., Amorim S., Reis R. L., Pires R. A., and Pashkuleva I., "Surfaces mimicking glycosaminoglycans trigger different response of stem cells via distinct fibronectin adsorption and reorganization", Acs Applied Materials & Interfaces, vol. 8, issue 42, pp. 28428 - 28436, doi:10.1021/acsami.6b04472, 2016. 7. Araújo A. R., Pereira D. M., Aroso I. M., Santos T., Batista M. T., Cerqueira M. T., Marques A. P., Reis R. L., and Pires R. A., "Cork extracts reduce UV-mediated DNA fragmentation and cell death", RSC Advances , issue 5, pp. 96151 - 96157, doi:0.1039/C5RA15712A, 2015. Papers in international scientific journals with referees (as co-author) 1. Aroso I. M., Araújo A. R., Pires R. A., and Reis R. L., "Cork: Current Technological Developments and Future Perspectives for this Natural, Renewable, and Sustainable Material", Acs Sustainable Chemistry & Engineering, vol. 5, issue 12, pp. 11130–11146, doi:10.1021/acssuschemeng.7b00751, 2017. 2. Aroso I. M., Araújo A. R., Fernandes J. S., Santos T., Batista M. T., Pires R. A., Mano J. F., and Reis R. L., "Hydroalcoholic extracts from the bark of Quercus suber L. (Cork): optimization of extraction conditions, chemical composition and antioxidant potential", Wood Science and Technology, vol. 51, issue 4, pp. 855-872, doi:10.1007/s00226-017-0904-y, 2017 Book Chapter 1. Araújo R. A., Reis R. L., Pires R. A. “Natural Polyphenols as Modulators of the Fibrillization of Islet Amyloid Polypeptide”, Advances in experimental medicine and biology 2020, 1250, 159-176.
